This article describes the case of Mary Barnes, who was 12 years old in 1894. After an illness Mary began to develop multiple personalities over a number of years. 10 distinct personalities were noted. Their appearance lasted anywhere from a number of weeks without interruption to a mere matter of minutes, never to return. Each of the personalities was distinct and would be accompanied with facial features, body abilities and knowledge. One personality was a deaf mute, one was blind, and one was paralyzed, several personalities had low intelligence levels. Dr. Wilson describes each of the personalities in detail, along with their arrival and departure dates. The author gives a brief overview of the Nervous System. Letters written by Mary’s different personalities are also included.